Isomer-specific effect of microRNA miR-29b on nuclear morphology
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چکیده
منابع مشابه
MicroRNA-29B (mir-29b) regulates the Warburg effect in ovarian cancer by targeting AKT2 and AKT3
Epithelial ovarian cancer (EOC) is the most lethal and aggressive gynecological malignancy, and abnormal cellular metabolism significantly contributes to cancer onset and progression. Here, we report that miR-29b negatively regulates AKT2/AKT3 expression, causing HK2/PKM2 downregulation and leading to a decreased Warburg effect and slowed ovarian cancer progression. Compared to normal ovaries, ...
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15 صفحه اولExpression of miR-29b in Malignant Tumors
MicroRNAs (miRNAs) are a class of single-stranded small molecule RNA with about 22 nucleotides in length (Bartel, 2009). These short RNA molecules are able to bind to specifics sites typically present in the three prime untranslated region (3’-UTR) of their target genes and mediate either mRNA decay with perfect base pairing or translational blockade with imperfect base pairing (Pillai et al., ...
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Abstract Background and Objective: Various cellular factors affect the process of HIV activity. One of these cellular factors are structures known as microRN that are expected to be involved in controlling HIV replication and infectivity. The expression of one or a set of them may represent the patient's clinical conditions. In this study, ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2018
ISSN: 0021-9258
DOI: 10.1074/jbc.ra117.001705